The feasibility, generalizability, and validity of randomized controlled trials (RCTs) may be compromised when patients have preferences for specific trial arms. The patient preference trial (PPT) design, which assigns at least a subset of the patients based on their preference rather than randomization, has been proposed as an alternative. The aim of this review was to provide an overview of the application of the PPT design in oncological research, with a particular focus on PPTs designed to assess the effectiveness of an intervention and provide recommendations on reporting.
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